Huge AddData folders

I am just preparing to transfer my data to a separate internal drive. The largest folders under my User folder are naturally my Pictures and my Video folders.

I am surprised to find out that the AppData folder takes up over 62 GB of storage.

1. Can I transfer AppData to my new internal hard drive (other than the system SSD)?
2. Can I trim down the AppData folders? If yes, how and what to remove?